Phencyclidine

Base Information

• Chemical Name: Phencyclidine
• CAS No.: 77-10-1
• Molecular Formula: C17H25 N
• Molecular Weight: 243.392
• Hs Code.: 2933330022
• European Community (EC) Number: 621-588-0
• UNII: J1DOI7UV76
• DSSTox Substance ID: DTXSID6023446
• Nikkaji Number: J4.441E
• Wikipedia: Phencyclidine
• Wikidata: Q407324
• NCI Thesaurus Code: C738
• Pharos Ligand ID: ZFS4CBHZQX9A
• Metabolomics Workbench ID: 53356
• ChEMBL ID: CHEMBL275528
• Mol file: 77-10-1.mol

Synonyms:1-(1-Phenylcyclohexyl)piperidine;Angel Dust;CL 395;CL-395;CL395;Dust, Angel;GP 121;GP-121;GP121;Phencyclidine;Phencyclidine Hydrobromide;Phencyclidine Hydrochloride;Sernyl;Serylan

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Phencyclidine

Chemical Property:

• Melting Point: 46.5℃
• Refractive Index: 1.5000 (estimate)
• Boiling Point: bp1.0 135-137°
• PKA: pKa 8.5 (Uncertain)
• Flash Point: 11 °C
• PSA: 3.24000
• Density: 0.9762 (rough estimate)
• LogP: 4.26980
• Storage Temp.: −20°C
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 243.198699802
• Heavy Atom Count: 18
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 23/24/25-39/23/24/25-11-61
• Safety Statements: 36/37-45-16-53

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Agents of Abuse
• Canonical SMILES: C1CCC(CC1)(C2=CC=CC=C2)N3CCCCC3

Technology Process of Phencyclidine

There total 11 articles about Phencyclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

piperidine (110-89-4) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + phenylmagnesium bromide → Phencyclidine (77-10-1)

Guidance literature:

piperidine; cyclohexanone; With 1,2,3-triazole; In toluene; at 108 - 114 ℃;

phenylmagnesium bromide; In tetrahydrofuran; toluene; at 24 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2005.06.066

Reference yield: 73.0%

phenylmagnesium bromide + 1-(1-Piperidin-1-yl-cyclohexyl)-1H-benzotriazole (120802-88-2) → Phencyclidine (77-10-1)

Guidance literature:

In diethyl ether; benzene; at 20 ℃;

DOI:10.1055/s-1989-27156

Reference yield: 58.0%

bromobenzene (108-86-1,52753-63-6) + 1-piperidinocyclohexylcarbonitrile (3867-15-0) → Phencyclidine (77-10-1)

Guidance literature:

bromobenzene; With iodine; magnesium; In tetrahydrofuran; diethyl ether;

1-piperidinocyclohexylcarbonitrile; In tetrahydrofuran; diethyl ether; Reflux;

upstream raw materials:

1-(1-Piperidin-1-yl-cyclohexyl)-1H-benzotriazole

piperidine

cyclohexanone

bromobenzene

Downstream raw materials:

N-[1-(3-hydroxyphenyl)cyclohexyl]piperidine

1-(1-phenylcyclohexyl)-2-cyanopiperidine

3-nitrophencyclidine

4-nitrophencyclidine

Refernces

• 1、 Ahmadi, Abbas,Khalili, Mohsen,Barzin, Mahnaz,Pooladi, Mohsen,Bakhtiari, Fatemeh,Barjeste, Maede,Nahri-Niknafs, Babak. "Synthesis and antinociception properties of phencyclidine derivatives with modified aromatic or cycloalkyl rings and amino group". . p. 457 - 464. Retrieved 2016/02/16.
• 2、 Ahmadi, Abbas,Solati, Jalal,Hajikhani, Ramin,Pakzad, Sara. "Synthesis and analgesic effects of methoxy-pyrrole derivative of phencyclidine on mice". scheme or table. p. 5429 - 5432. Retrieved 2012/07/27.