3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

Base Information

Chemical Name:3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate
CAS No.:1427555-40-5
Molecular Formula:C₂₂H₂₅ClN₄O₂
Molecular Weight:412.919
Hs Code.:

Synonyms:3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

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Chemical Property of 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

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Technology Process of 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

There total 8 articles about 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1334711-86-2
4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine

: 1427555-40-5
3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

Guidance literature:: bis(trichloromethyl) carbonate; N-tert-butoxycarbonyl-3-aminopropanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h;

4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 72h;

With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield: 16.0%

: C₂₇H₃₃ClN₄O₄

: 1427555-40-5
3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 271-29-4
6-azaindole

: 1427555-40-5
3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol / 18 h / 70 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 90 °C / 67506.8 Torr

3.1: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 2 h

5.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / dichloromethane / 3 h

5.2: 72 h

6.1: trifluoroacetic acid / dichloromethane / 2 h

With potassium phosphate; copper(l) iodide; bis(trichloromethyl) carbonate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; N,N`-dimethylethylenediamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;