N-methyl-α-cyclohexylbenzenemethanamine

Base Information

• Chemical Name: N-methyl-α-cyclohexylbenzenemethanamine
• CAS No.: 174316-26-8
• Molecular Formula: C₁₄H₂₁N
• Molecular Weight: 203.327
• Mol file: 174316-26-8.mol

Synonyms:N-methyl-α-cyclohexylbenzenemethanamine

Chemical Property of N-methyl-α-cyclohexylbenzenemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-methyl-α-cyclohexylbenzenemethanamine

There total 3 articles about N-methyl-α-cyclohexylbenzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

N-(cyclohexyl(phenyl)methyl)formamide (42071-06-7) → N-methyl-α-cyclohexylbenzenemethanamine (174316-26-8)

Guidance literature:

N-(cyclohexyl(phenyl)methyl)formamide; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h; Cooling with ice;

DOI:10.1021/acs.jmedchem.1c00633

Reference yield:

N-Benzylidenemethylamine (622-29-7) + cyclohexylmagnesium bromide (931-50-0) → N-methyl-α-cyclohexylbenzenemethanamine (174316-26-8)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01177a080

Reference yield:

Cyclohexyl phenyl ketone (712-50-5) → N-methyl-α-cyclohexylbenzenemethanamine (174316-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) HCONH₂, HCO₂H, (ii) /BRN= 773835/, benzene

2: LiAlH₄ / diethyl ether / Heating

With lithium aluminium tetrahydride; In diethyl ether;

upstream raw materials:

N-Benzylidenemethylamine

cyclohexylmagnesium bromide

N-(cyclohexyl(phenyl)methyl)formamide

Cyclohexyl phenyl ketone

Downstream raw materials:

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(cyclohexyl-phenyl-methyl)-methyl-amino]-ethyl} ester 5-methyl ester

2-(Cyclohexyl-methyl-amino)-N-(cyclohexyl-phenyl-methyl)-N-methyl-acetamide

2-Cyclohexylamino-N-(cyclohexyl-phenyl-methyl)-N-methyl-acetamide

3-Oxobutanoic acid 2-<(cyclohexylphenylmethyl)methylamino>ethyl ester

Refernces