2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide

Base Information

• Chemical Name: 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide
• CAS No.: 67879-91-8
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 67879-91-8.mol

Synonyms:2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide

Chemical Property of 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide

There total 2 articles about 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-methoxy-4,5-methylenedioxybenzaldehyde (5780-00-7) + diethyl (2-oxo-2-(piperidin-1-yl)ethyl)phosphonate (27465-67-4) → 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide (67879-91-8)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; 0 degC to room temp. in 12h;

DOI:10.1002/jlac.198219820615

Reference yield:

2-methoxy-4,5-methylenedioxybenzaldehyde (5780-00-7) → 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide (67879-91-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / CH₃ONa / tetrahydrofuran; ethanol / 5-10 degC to room temp. in 12h

2: 81 percent / NaOH / H₂O; ethanol / 1.) 12h, room temp.; 2.) 2.5h, 50 degC

3: SOCl₂ / benzene; dimethylformamide / 50 °C

4: 93 percent / benzene; dimethylformamide / 2 h / Ambient temperature

With sodium hydroxide; thionyl chloride; sodium methylate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; benzene;

DOI:10.1002/jlac.198219820615

Reference yield:

2-methoxy-4,5-methylenedioxy-trans-cinnamoyl piperidide (67879-91-8) → piperidine (110-89-4) + 2-Methoxy-4,5-methylendioxyzimtsaeure (73490-45-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; Yield given. Multistep reaction; 1.) ethyleneglycol, H₂O, 2.) ethyleneglycol, H₂O;

DOI:10.1016/S0031-9422(00)94536-9

upstream raw materials:

2-methoxy-4,5-methylenedioxybenzaldehyde

diethyl (2-oxo-2-(piperidin-1-yl)ethyl)phosphonate

Downstream raw materials:

piperidine

2-Methoxy-4,5-methylendioxyzimtsaeure