2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

Base Information

Chemical Name:2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide
CAS No.:1285514-08-0
Molecular Formula:C₂₄H₂₅N₃O₃
Molecular Weight:403.481
Hs Code.:

Synonyms:2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

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Chemical Property of 2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

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Technology Process of 2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

There total 8 articles about 2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285516-86-0
1,1-dimethylethyl (2R)-2-[({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}oxy)methyl]-1-pyrrolidinecarboxylate

: 1285514-08-0
2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

Guidance literature:: 1,1-dimethylethyl (2R)-2-[({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}oxy)methyl]-1-pyrrolidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 25 ℃; Cooling with ice;

With sodium hydrogencarbonate; In dichloromethane; water; pH=7 - 8;

Reference yield:

: 2150-46-1
Methyl 2,5-dihydroxybenzoate

: 1285514-08-0
2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 7 h / Reflux

2.1: Reflux

3.1: potassium hydroxide; water / ethanol / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C

5.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C

5.2: 18 h / 75 °C

6.1: trifluoroacetic acid / dichloromethane / 25 °C / Cooling with ice

6.2: pH 7 - 8

With water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 100-39-0
benzyl bromide

: 1285514-08-0
2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2R)-2-pyrrolidinylmethyl]oxy}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 7 h / Reflux

1.3: Reflux

2.1: potassium hydroxide; water / ethanol / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C

4.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C

4.2: 18 h / 75 °C

5.1: trifluoroacetic acid / dichloromethane / 25 °C / Cooling with ice

5.2: pH 7 - 8

With water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;