N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester

Base Information

• Chemical Name: N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester
• CAS No.: 316828-32-7
• Molecular Formula: C₂₉H₃₂Cl₃N₃O₇
• Molecular Weight: 640.948

Synonyms:N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester

Chemical Property of N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester

There total 8 articles about N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2(R)-(carbobenzoxy)amino-4-methylpentanoic acid p-nitrophenyl ester (52235-17-3) + Nα-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester (316828-30-5) → Nin-L-benzyloxycarbonylleucyl-Na-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester (316828-32-7)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 60h; sonification;

DOI:10.1021/ol017215d

Reference yield: 95.0%

Z-Leu-ONp (1738-87-0) + Nα-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester (316828-30-5) → Nin-L-benzyloxycarbonylleucyl-Na-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester (316828-32-7)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 60h;

DOI:10.1021/jo0264980

Reference yield: 67.0%

Nin-L-benzyloxycarbonylleucyl-Na-2,2,2-trichloroethoxycarbonyl-2-iodo-D-tryptophan methyl ester (316828-36-1) → Nin-L-benzyloxycarbonylleucyl-Na-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester (316828-32-7) + methyl (αR,2S)-2,3-dihydro-2-(2-methylpropyl)-3-oxo-1-[(phenylmethoxy)carbonyl]-α-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1H-imidazo(1,2-a)indole-9-propanoate (316828-34-9)

Guidance literature:

With potassium carbonate; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 105 ℃; for 2h;

DOI:10.1021/jo0264980

upstream raw materials:

Z-Leu-ONp

N_α-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester

N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-2-iodo-D-tryptophan methyl ester

2(R)-(carbobenzoxy)amino-4-methylpentanoic acid p-nitrophenyl ester

Downstream raw materials:

N_in-L-benzyloxycarbonylleucyl-N_a-2,2,2-trichloroethoxycarbonyl-2-iodo-D-tryptophan methyl ester

C₂₈H₂₈Cl₃N₃O₇

C₃₂H₃₂N₄O₆

methyl (αR,2S)-2,3-dihydro-2-(2-methylpropyl)-3-oxo-1-[(phenylmethoxy)carbonyl]-α-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1H-imidazo(1,2-a)indole-9-propanoate

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