6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

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Chemical Name:6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane
CAS No.:126615-40-5
Molecular Formula:C₃₉H₅₄O₄Si
Molecular Weight:614.941
Hs Code.:

Synonyms:6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

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Chemical Property of 6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

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Technology Process of 6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

There total 9 articles about 6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 51440-56-3
1-Methoxy-4-(1-methoxy-vinyl)-benzene

: 126720-99-8
1-<(tert-Butyldiphenylsilyl)oxy>-2(R),4(S),6(R),9-tetramethyl-7(E)-decene-3(R),5(S)-diol

: 126615-40-5
6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

Guidance literature:: With pyridinium p-toluenesulfonate; molecular sieve; In dichloromethane; for 1h;
DOI:10.1021/jo00296a044

Reference yield:

: 126720-95-4
4(S)-<1(S)-Methyl-2-cyanoethyl>-2,2,5(R)-trimethyl-1,3-dioxane

: 126615-40-5
6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / methanol / Heating

3: LDA

4: 2) (Ph₃P)4Pd / 1) appropriate sodium salt

5: decarbomethoxylation

6: Lit_.: Ziegler, F_. E_.; Cain, W_. T_. J_. Org_. Chem_. 1989, 54, 3347

7: 94 percent / pyridinium tosylate / molecular sieve / CH₂Cl₂ / 1 h

With hydrogenchloride; pyridinium p-toluenesulfonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; molecular sieve; In methanol; dichloromethane;
DOI:10.1021/jo00296a044

Reference yield:

: 126615-39-2
3(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-methyl-5(S)-<1(R)-methyl-2-hydroxyethyl>dihydro-2(3H)-furanone

: 126615-40-5
6(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2(S),5(S)-dimethyl-2-(p-methoxyphenyl)-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: 0.83 g / DMAP, Et₃N / CH₂Cl₂ / 13 h / Ambient temperature

2: Lit_.: Ziegler, F_. E_.; Cain, W_. T_. J_. Org_. Chem_. 1989, 54, 3347

3: 94 percent / pyridinium tosylate / molecular sieve / CH₂Cl₂ / 1 h

With dmap; pyridinium p-toluenesulfonate; triethylamine; molecular sieve; In dichloromethane;
DOI:10.1021/jo00296a044