(1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:(1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1430747-28-6
Molecular Formula:C₁₈H₃₁NO₄
Molecular Weight:325.448
Hs Code.:

Synonyms:(1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of (1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of (1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 3 articles about (1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 1430747-25-3
(1R,3r,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430747-28-6
(1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen; In isopropyl alcohol; at 80 ℃; under 11251.1 Torr; Autoclave;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1430747-28-6
(1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 20 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.33 h / 20 °C

2.2: 60 h / 90 °C

2.3: 0.17 h

3.1: sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 80 °C / 11251.1 Torr / Autoclave

With sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In dimethyl sulfoxide; isopropyl alcohol; acetonitrile;

Reference yield:

: 370-78-5
4-fluorophenyl phenylmethyl ether

: 1430747-28-6
(1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.33 h / 20 °C

1.2: 60 h / 90 °C

1.3: 0.17 h

2.1: sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 80 °C / 11251.1 Torr / Autoclave

With sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; In dimethyl sulfoxide; isopropyl alcohol;