370-78-5

Basic information

• Product Name: 4-BENZYLOXYFLUOROBENZENE
• Synonyms: 4-BENZYLOXYFLUOROBENZENE;1-BENZYLOXY-4-FLUOROBENZENE;4-BENZYLOXYFLUOROBENZENE 98%;1-Benzyloxy-4-fluorobzenzene;1-Benzyloxy-4-fluorobenzene98%
• CAS NO: 370-78-5
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.22
• Mol File: 370-78-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 54-56°C
• Boiling Point: 301 °C at 760 mmHg
• Flash Point: 114.2 °C
• Appearance: /
• Density: 1.133 g/cm³
• Vapor Pressure: 0.00193mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BENZYLOXYFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXYFLUOROBENZENE(370-78-5)
• EPA Substance Registry System: 4-BENZYLOXYFLUOROBENZENE(370-78-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 370-78-5(Hazardous Substances Data)

Usage

General Description

4-Benzyloxyfluorobenzene is a chemical compound with the molecular formula C13H11FO and is classified as an aryl fluoride. It is commonly used as a building block and intermediate in organic synthesis for the production of pharmaceuticals and agrochemicals. 4-BENZYLOXYFLUOROBENZENE is characterized by its benzene ring that is substituted with a benzyloxy group and a fluorine atom. 4-Benzyloxyfluorobenzene is known for its reactivity and versatility in various chemical reactions, making it a valuable tool in the field of organic chemistry. It is important to handle this compound with caution as it may pose health risks if not used properly.

InChI:InChI=1/C13H11FO/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9H,10H2

Upstream product

• 70987-78-9 (S)-Glycidyl tosylate 
• 100-39-0 benzyl bromide 
• 754226-40-9 4,4,5,5,-tetramethyl-2-[4-(phenylmethoxy)phenyl]-1,3,2-dioxaborolane 
• 371-41-5 4-Fluorophenol 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 145745-05-7 (4-(benzyloxy)phenyl)tri-n-butylstannane 
• 540-38-5 p-Iodophenol 
• 146631-00-7 [4-(benzyloxy)phenyl]boronic acid 
• 19578-68-8 4-(4-benzyloxyphenyl) iodide 
• 540-36-3 para-difluorobenzene 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 

Downstream Products

• 1430747-28-6 (1R,3r,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-22-0 (1R,3r,5S)-tert-butyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-26-4 (1R,3r,5S)-tert-butyl 3-((1s,4S)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-24-2 (1R,3R,5S)-((S)-1,1,1-trifluoropropan-2-yl) 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-25-3 (1R,3r,5S)-tert-butyl 3-(4-(benzyloxy)phenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 371-41-5 4-Fluorophenol 

Relevant articles and documents

Transition-Metal-Free and Base-Promoted Carbon-Heteroatom Bond Formation via C-N Cleavage of Benzyl Ammonium Salts

A facile and general method for constructing carbon-heteroatom (C-P, C-O, C-S, and C-N) bonds via C-N cleavage of benzyl ammonium salts under transition-metal-free conditions was reported. The combination of t-BuOK and 18-crown-6 enabled a wide range of substituted benzyl ammonium salts to couple readily with different kinds of heteroatom nucleophiles, i.e. hydrogen phosphoryl compounds, alcohols, thiols, and amines. Good functional group tolerance was demonstrated. The scale-up reaction and one-pot synthesis were also successfully performed.

α-Lithiobenzyloxy as a Directed Metalation Group in ortho-Lithiation Reactions

The α-lithiobenzyloxy group, easily generated from aryl benzyl ethers by selective α-lithiation with t-BuLi at low temperature, behaves as a directed metalation group (DMG) providing a direct access to o-lithiophenyl α-lithiobenzyl ethers. This ortho-directing effect is reinforced in substrates bearing an additional methoxy group at the meta position. The generated dianions can be reacted with a selection of electrophiles including carboxylic esters and dihalosilanes or germanes, which afford interesting benzofuran, sila(germa)dihydrobenzofuran, and silachroman derivatives from simple aryl benzyl ethers.

Organic Photoredox Catalysis for Pschorr Reaction: A Metal-Free and Mild Approach to 6 H-Benzo[ c[chromenes

An expedient organic photoredox Pschorr reaction has been developed that opens up a synthetic route to 6 H-benzo[ c[chromenes. The process can be performed under mild conditions by using eosin Y as a photoredox catalyst and acetonitrile as the solvent. Th