(2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

Base Information

Chemical Name:(2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol
CAS No.:105878-97-5
Molecular Formula:C₁₃H₁₇NO₅
Molecular Weight:267.282
Hs Code.:

Synonyms:(2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

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Chemical Property of (2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

Chemical Property:

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Technology Process of (2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

There total 15 articles about (2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 100937-52-8,186759-56-8,187339-50-0
1,4-dideoxy-1,4-imino-D-arabitol

: 501-53-1,94274-21-2
benzyl chloroformate

: 105878-97-5
(2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

Guidance literature:: With sodium hydroxide; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.2807

Reference yield: 46.0%

: 96-26-4,26776-70-5
dihydroxyacetone

: 67561-03-9
N-benzyloxycarbonylglycinal

: 105878-97-5
(2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

Guidance literature:: dihydroxyacetone; N-benzyloxycarbonylglycinal; With D-fructose-6-phosphate aldolase mutant A₁₆₅G; In N,N-dimethyl-formamide; at 25 ℃; for 24h; pH=7; Enzymatic reaction;

With palladium 10% on activated carbon; hydrogen; In ethanol; under 2585.81 Torr;
DOI:10.1039/c3ob27343a

Reference yield:

: 108692-47-3
(2R,3R,4R)-2-hydroxymethyl-3,4-dihydro-2H-pyrrole-3,4-diol

: 105878-97-5
(2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / 10percent Pd-C / H₂O / 4 h / 3040 Torr / Ambient temperature

2: 88 percent / 1N aq. NaOH / 1 h / Ambient temperature

With sodium hydroxide; hydrogen; palladium on activated charcoal; In water;
DOI:10.1248/cpb.39.2807