67561-03-9

Basic information

• Product Name: Carbamic acid, (2-oxoethyl)-, phenylmethyl ester
• CAS NO: 67561-03-9
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.202
• Mol File: 67561-03-9.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (2-oxoethyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-oxoethyl)-, phenylmethyl ester(67561-03-9)
• EPA Substance Registry System: Carbamic acid, (2-oxoethyl)-, phenylmethyl ester(67561-03-9)

Safety Data

• Hazardous Substances Data: 67561-03-9(Hazardous Substances Data)

Upstream product

• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 79-37-8 oxalyl dichloride 
• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 6269-99-4 N-(2-hydroxyethyl)-2-phenylacetamide 
• 30830-47-8 benzyl N-chlorocarbamate 
• 501-53-1 benzyl chloroformate 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 114790-39-5 benzyl N-(2,2-dimethoxyethyl)carbamate 
• 121505-94-0 N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide 
• 5041-33-8 N-(Benzyloxycarbonyl)allylamine 
• 31236-62-1 (2-Ethoxy-2-methoxy-ethyl)-carbamic acid benzyl ester 

Downstream Products

• 74597-66-3 6-Benzyloxycarbonylaminomethyl-2-methoxy-5,6-dihydro-2H-pyran 
• 92506-74-6 (R)-2-(Benzyloxycarbonylamino-methyl)-thiazolidine-4-carboxylic acid methyl ester 
• 92506-74-6 (S)-2-(Benzyloxycarbonylamino-methyl)-thiazolidine-4-carboxylic acid methyl ester 
• 119372-46-2 Ethyl 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy butanoate 
• 109364-18-3 Z-Glyψ(CH2NH)Trp-OMe 
• 158387-33-8 6-<<(2-aminoethyl)carbobenzoxy>amino>-2-<<1-<(ethoxycarbonyl)methyl>-2-oxo-2,3,4,5-tetrahydro-1H-benzazepin-3-yl>amino>hexanoic acid ethyl ester 
• 307002-11-5 benzyl {2-[2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl]-2-(1H-indol-3-yl)ethyl}carbamate 
• 625457-45-6 ethyl (2E)-4-[(benzyloxycarbonyl)amino]but-2-enoate 
• 192725-46-5 N-((benzyloxycarbonyl)amino)ethyl valine methyl ester 
• 1037210-22-2 C₃₈H₅₄N₂O₄ 
• 105878-97-5 (2R,3R,4R)-N-benzyloxycarbonyl-2-(hydroxymethyl)pyrrolidine-3,4-diol 
• 1427173-83-8 (2R,3R,4R)-N-benzyloxycarbonyl-2-((glycineamidyl)methyl)-3,4-dihydroxypyrrolidine 
• 1427173-85-0 (2R,3R,4R)-N-benzyloxycarbonyl-2-(((S)-alanineamidyl)methyl)-3,4-dihydroxypyrrolidine 
• 1427173-94-1 (2R,3R,4R)-N-benzyloxycarbonyl-2-(((S)-valineamidyl)methyl)-3,4-dihydroxypyrrolidine 

Relevant articles and documents

Oxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters

A highly diastereoselective one-pot synthesis of the 1,3-diamino-2-alcohol unit bearing three continuous stereocenters is described. This method utilizes 2-oxyenamides as a novel type of building block for the rapid assembly of the 1,3-diamine scaffold containing an additional stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)-oxyenamides is reported as well.

Synthetic method of chiral piperazidone derivative

The invention relates to a synthetic method of a chiral piperazidone derivative. The synthetic method comprises the following steps: performing an oxidation reaction on ethanolamine with a protectivegroup in a formula (I) to obtain aminoacetaldehyde with a protective group in a formula (II); in an alcohol solvent, performing a reduced amination reaction on the aminoacetaldehyde with the protective group in the formula (II) and amino acid ester in the presence of a reducing agent to obtain the chiral piperazidone derivative in the formula (II), wherein the reduced amination reaction temperature is -10 DEG C to 0 DEG C, and the amino acid ester is L-type amino acid ester or D-type amino acid ester; and in the alcohol solvent, performing a de-protection reaction on the chiral piperazidone derivative in the formula (II) and forming a ring to obtain a chiral piperazidone derivative in a formula (IV), wherein a reaction route is shown as follows: the protective group X is benzoxo carbonyl or tert-butyoxo carbonyl; R is methyl, ethyl, isopropyl, isobutyl, hydroxyethyl, benzyl, p-hydroxybenzyl and the like; and R' is methyl, ethyl and the like.

Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites

The protein arginine N-methyltransferases (PRMTs) are a family of enzymes that function by specifically transferring a methyl group from the cofactor S-adenosyl-l-methionine (AdoMet) to the guanidine group of arginine residues in target proteins. The most notable is the PRMT-mediated methylation of arginine residues that are present in histone proteins which can lead to chromatin remodelling and influence gene transcription. A growing body of evidence now implicates dysregulated PRMT activity in a number of diseases including various forms of cancer. The development of PRMT inhibitors may therefore hold potential as a means of developing new therapeutics. We here report the synthesis and evaluation of a series of small molecule PRMT inhibitors designed to simultaneously occupy the binding sites of both the guanidino substrate and AdoMet cofactor. Potent inhibition and surprising selectivity were observed when testing these compounds against a panel of methyltransferases.