L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester

Base Information

• Chemical Name: L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester
• CAS No.: 154415-61-9
• Molecular Formula: C₂₀H₂₇IN₂O₆
• Molecular Weight: 518.349
• Mol file: 154415-61-9.mol

Synonyms:L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester

Chemical Property of L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester

There total 4 articles about L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl (2S,3S)-2,3-epoxysuccinate (63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7) + 3-iodo-L-tyrosylamido(3-methyl)butane (154415-70-0) → L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester (154415-61-9)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In chloroform; for 3h; Ambient temperature;

DOI:10.1016/0223-5234(93)90046-H

Reference yield:

1-amino-3-methylbutane (107-85-7) → L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester (154415-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / CHCl₃ / 3 h / Ambient temperature

2: 85 percent / HCl / ethyl acetate / 3 h / Ambient temperature

3: 60 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CHCl₃ / 3 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In chloroform; ethyl acetate;

DOI:10.1016/0223-5234(93)90046-H

Reference yield:

N-tert-butyloxycarbonyl-3-iodo-L-tyrosine (71400-63-0,478183-68-5) → L-trans-epoxysuccinyl-3-iodo-L-tyrosylamido(3-methyl)butane ethylester (154415-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / CHCl₃ / 3 h / Ambient temperature

2: 85 percent / HCl / ethyl acetate / 3 h / Ambient temperature

3: 60 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CHCl₃ / 3 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In chloroform; ethyl acetate;

DOI:10.1016/0223-5234(93)90046-H

upstream raw materials:

ethyl (2S,3S)-2,3-epoxysuccinate

3-iodo-L-tyrosylamido(3-methyl)butane

1-amino-3-methylbutane

N-tert-butyloxycarbonyl-3-iodo-L-tyrosine