2-isopropyl-5-methyl-aniline

Base Information

• Chemical Name: 2-isopropyl-5-methyl-aniline
• CAS No.: 2437-39-0
• Molecular Formula: C10H15 N
• Molecular Weight: 149.236
• Hs Code.: 2921430090
• Mol file: 2437-39-0.mol

Synonyms:Thymylamine(6CI,8CI); 2-Isopropyl-5-methylaniline; 2-Isopropyl-5-methylphenylamine;3-Cymidine; 6-Isopropyl-m-toluidine; p-Cymen-3-amine; p-Cymene, 3-amino-

Chemical Property of 2-isopropyl-5-methyl-aniline

Chemical Property:

• Boiling Point: 241.1±9.0 °C(Predicted)
• PKA: 4.55±0.10(Predicted)
• PSA: 26.02000
• Density: 0.944±0.06 g/cm3(Predicted)
• LogP: 3.28180

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-isopropyl-5-methyl-aniline

There total 13 articles about 2-isopropyl-5-methyl-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-menthan-3-one oxime (1198-91-0,21002-69-7,26134-50-9,37886-68-3,49775-31-7,49805-45-0,49805-46-1,49805-47-2,65620-72-6,114129-78-1,19096-86-7,165874-36-2) → 2-isopropyl-5-methyl-phenylamine (2437-39-0)

Guidance literature:

With Pd(OH)x/LDH; In N,N-dimethyl acetamide; at 150 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.7b07347

Reference yield: 95.0%

→ 2-isopropyl-5-methyl-phenylamine (2437-39-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 - 24 ℃; Inert atmosphere;

Reference yield: 79.0%

4-methyl-2-nitro-1-(prop-1-en-2-yl)benzene (1449199-73-8) → 2-isopropyl-5-methyl-phenylamine (2437-39-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2015.06.021

upstream raw materials:

thymol

5-isopropyl-2-methylphenylamine

p-menth-1-en-3-one oxime

sodium acetate

Downstream raw materials:

thymol

N-(2-isopropyl-5-methylphenyl)acetamide

4-bromo-2-isopropyl-5-methyl aniline