(Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

Base Information

Chemical Name:(Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate
CAS No.:1219452-63-7
Molecular Formula:C₁₃H₁₂ClNO₅
Molecular Weight:297.695
Hs Code.:

Synonyms:(Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

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Chemical Property of (Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

Chemical Property:

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Technology Process of (Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

There total 3 articles about (Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 106098-23-1
(Z)-3-chloro-3-(4-nitrophenyl)acrylaldehyde

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1219452-63-7
(Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; at 50 ℃; for 12h; Neat (no solvent);
DOI:10.1080/00397910903262187

Reference yield: 60.0%

: 106098-23-1
(Z)-3-chloro-3-(4-nitrophenyl)acrylaldehyde

: 70-55-3
toluene-4-sulfonamide

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1219452-63-7
(Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

: 1254255-24-7
(Z)-methyl 5-chloro-2-methylene-3-(4-tolylsulfonamido)-5-(4-nitrophenyl)pent-4-enoate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; aluminum (III) chloride; at 20 ℃; for 1h; Neat (no solvent);
DOI:10.3184/030823410X12627215361201

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1219452-63-7
(Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-(4-nitrophenyl)pent-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: bis(trichloromethyl) carbonate

2: 1,4-diaza-bicyclo[2.2.2]octane

With 1,4-diaza-bicyclo[2.2.2]octane; bis(trichloromethyl) carbonate; 1: Vilsmeier formylation / 2: Baylis-Hillman reaction;
DOI:10.3987/COM-11-12333