C₃₇H₃₅ClFN₃O₇S

Base Information

• Chemical Name: C₃₇H₃₅ClFN₃O₇S
• CAS No.: 1234779-91-9
• Molecular Formula: C₃₇H₃₅ClFN₃O₇S
• Molecular Weight: 720.218
• Mol file: 1234779-91-9.mol

Synonyms:C₃₇H₃₅ClFN₃O₇S

Chemical Property of C₃₇H₃₅ClFN₃O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₃₅ClFN₃O₇S

There total 19 articles about C₃₇H₃₅ClFN₃O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-6-iodo-4-methylaniline (217314-44-8) → C37H35ClFN3O7S (1234779-91-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine

2.1: copper(l) iodide / N,N-dimethyl-formamide / 100 °C

3.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 15 °C

3.2: 20 °C

4.1: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 5 - 22 °C

5.1: tetrahydrofuran / 1 h / 40 °C / Inert atmosphere

6.1: tetrahydrofuran / 1.4 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 1.1: |Sonogashira Cross-Coupling;

DOI:10.1021/op300249q

Reference yield:

2-fluoro-4-methylaniline (452-80-2) → C37H35ClFN3O7S (1234779-91-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: aluminum (III) chloride; boron trichloride; sodium hydroxide / dichloromethane; water / 14 h / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / water; pentan-1-ol / 2.42 h / 20 °C / Reflux

3.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 15 °C

3.2: 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 22 °C

5.1: tetrahydrofuran / 1 h / 40 °C / Inert atmosphere

6.1: tetrahydrofuran / 1.4 h / 60 °C

With aluminum (III) chloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; boron trichloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; pentan-1-ol; water; toluene;

DOI:10.1021/op300249q

Reference yield:

2-fluoro-4-methyl-6-((trimethylsilyl)ethynyl)aniline → C37H35ClFN3O7S (1234779-91-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper(l) iodide / N,N-dimethyl-formamide / 100 °C

2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 15 °C

2.2: 20 °C

3.1: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 5 - 22 °C

4.1: tetrahydrofuran / 1 h / 40 °C / Inert atmosphere

5.1: tetrahydrofuran / 1.4 h / 60 °C

With copper(l) iodide; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/op300249q

upstream raw materials:

4-chlorobenzoyl chloride

tert-butyl-4-bromobenzoate

2-fluoro-4-methylaniline

7-fluoro-5-methyl-2-(trimethylsilyl)-1H-indole