Ripisartan

Base Information

Chemical Name:Ripisartan
CAS No.:148504-51-2
Molecular Formula:C23H22 N8 O
Molecular Weight:426.47
Hs Code.:
UNII:7LQ7OQP653
DSSTox Substance ID:DTXSID10164001
Nikkaji Number:J606.604F
Wikidata:Q27268532
NCI Thesaurus Code:C90658
Pharos Ligand ID:JZC7JA5JABVP
ChEMBL ID:CHEMBL312104
Mol file:148504-51-2.mol

Synonyms:5-methyl-7-n-propyl-8-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-(1,2,4)-triazolo(1,5-c)pyrimidin-2(3H)-one;UP 269-6;UP-269-6

Suppliers and Price of Ripisartan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
RIPISARTAN 95.00%
5MG
$ 502.17

Total 5 raw suppliers

Chemical Property of Ripisartan

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：117.51000
Density:1.42g/cm³
LogP:3.11640
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:426.19165736
Heavy Atom Count:32
Complexity:813

Purity/Quality:

95% ^*data from raw suppliers

RIPISARTAN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1=C(C2=NC(=O)NN2C(=N1)C)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5

Technology Process of Ripisartan

There total 8 articles about Ripisartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 148475-98-3
8-<(2'-cyanobiphenyl-4-yl)methyl>-2-hydroxy-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine

: 148504-51-2
UP 269-6

Guidance literature:: With azidotrimethyltin; In benzene-d6; at 115 ℃; for 24h;
DOI:10.1002/jhet.5570330450

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 148504-51-2
UP 269-6

Guidance literature:: Multi-step reaction with 6 steps

1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating

2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h

3: POCl₃ / toluene / 8 h / Heating

4: NH₂NH₂*H₂O / ethanol / 2 h / Heating

5: 91 percent / various solvent(s) / 6 h / 160 - 165 °C

6: 86 percent / Me₃SnN₃ / benzene-d6 / 24 h / 115 °C

With sodium methylate; azidotrimethyltin; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; benzene-d6; toluene;
DOI:10.1002/jhet.5570330450

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 148504-51-2
UP 269-6

Guidance literature:: Multi-step reaction with 6 steps

1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating

2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h

3: POCl₃ / toluene / 8 h / Heating

4: NH₂NH₂*H₂O / ethanol / 2 h / Heating

5: 91 percent / various solvent(s) / 6 h / 160 - 165 °C

6: 86 percent / Me₃SnN₃ / benzene-d6 / 24 h / 115 °C

With sodium methylate; azidotrimethyltin; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; benzene-d6; toluene;
DOI:10.1002/jhet.5570330450