di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

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Chemical Name:di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate
CAS No.:1257767-63-7
Molecular Formula:C₃₀H₃₉N₃O₈
Molecular Weight:569.655
Hs Code.:

Synonyms:di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

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Technology Process of di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

There total 2 articles about di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 923568-89-2
tert-butyl 5-methoxy-2-oxo-3-phenylindoline-1-carboxylate

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 1257767-63-7
di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: With (1S)-(6-(3-((4-((S)-hydroxy((2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-yloxy)methyl)benzyloxy)quinolin-4-yl)((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol; In toluene; at -70 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol102493q

Reference yield:

: 923568-89-2
tert-butyl 5-methoxy-2-oxo-3-phenylindoline-1-carboxylate

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 1257767-63-7
di-tert-butyl 1-((R)-1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

: (S)-di-tert-butyl 1-(1-(tert-butoxycarbonyl)-5-methoxy-2-oxo-3-phenylindolin-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: With chiral thiourea modified polymers prepared from 5,5′,6,6′-tetrahydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobisindane, 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile and (1R,2R)-trans-2-(1-piperidinyl)cyclohexylamine; In toluene; at -40 ℃; for 40h; Reagent/catalyst; Overall yield = 90 percent; Overall yield = 51 mg; enantioselective reaction;
DOI:10.1039/d0ob01373k