(R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine

Base Information

• Chemical Name: (R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine
• CAS No.: 1265624-62-1
• Molecular Formula: C₁₉H₂₃NO
• Molecular Weight: 281.398
• Mol file: 1265624-62-1.mol

Synonyms:(R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine

Chemical Property of (R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine

There total 2 articles about (R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-Methoxy-1-tetralone (33892-75-0) + (S)-1-phenyl-ethylamine (2627-86-3) → (R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine (1265624-62-1)

Guidance literature:

5-Methoxy-1-tetralone; (S)-1-phenyl-ethylamine; With trifluoroacetic acid; In toluene; Reflux;

With sodium tetrahydroborate; In ethanol; at -18 - 0 ℃; for 4h; optical yield given as %de;

DOI:10.1021/jm1013133

Reference yield: 70.0%

5-Methoxy-1-tetralone (33892-75-0) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine (1265624-62-1)

Guidance literature:

5-Methoxy-1-tetralone; (R)-1-phenyl-ethyl-amine; With trifluoroacetic acid; In toluene; Reflux;

With sodium tetrahydroborate; In ethanol; at -18 - 0 ℃; for 4h; optical yield given as %de;

DOI:10.1021/jm1013133

Reference yield:

(R,R)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-(1-methylbenzyl)amine (1265624-62-1) → (+)-(R)-N-[(5-methoxy-1,2,3,4-tetrahydronaphthalen)-1-yl]-2-(4-cyclohexylpiperazine-1-yl)acetamide dihydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen

2: sodium hydrogencarbonate / acetonitrile / Reflux

With palladium on carbon; hydrogen; sodium hydrogencarbonate; In acetonitrile;

DOI:10.1021/jm1013133

upstream raw materials:

5-Methoxy-1-tetralone

(S)-1-phenyl-ethylamine

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

(R)-(-)-5-methoxy-1,2,3,4-tetrahydro-1-naphthalenamine