5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Base Information

• Chemical Name: 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine
• CAS No.: 1308247-08-6
• Molecular Formula: C₁₉H₂₂N₄O
• Molecular Weight: 322.41
• Mol file: 1308247-08-6.mol

Synonyms:5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property of 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

There total 5 articles about 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyrrolidine (123-75-1) + 2-[4-(2-bromoethoxy)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyridine (898533-77-2) → 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine (1308247-08-6)

Guidance literature:

In chloroform; at 20 ℃;

DOI:10.2174/157017811795038377

Reference yield: 54.6%

C13H16N2O (46745-39-5) + 1-amino-2-methylpyridinium mesitylenesulfonate (39996-42-4) → 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine (1308247-08-6)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 24h; Cooling with ice;

DOI:10.2174/157340610791321505

Reference yield:

4-(2-tetrahydro-1H-1-pyrrolylethoxy)benzaldehyde (26116-47-2) → 5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine (1308247-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; oxygen; copper; ammonium chloride / 24 h / 60 °C

2: potassium hydroxide / ethanol / 24 h / 20 °C / Cooling with ice

With pyridine; oxygen; copper; ammonium chloride; potassium hydroxide; In ethanol;

DOI:10.2174/157340610791321505

upstream raw materials:

C₁₃H₁₆N₂O

1-amino-2-methylpyridinium mesitylenesulfonate

4-(2-tetrahydro-1H-1-pyrrolylethoxy)benzaldehyde

pyrrolidine