3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
• CAS No.: 195250-44-3
• Molecular Formula: C₂₀H₁₅N₃O₅S
• Molecular Weight: 409.422

Synonyms:3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property of 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 2 articles about 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3-(3-methoxy-phenyl)-ureido]-4-methyl-5-(4-nitro-phenyl)-thiophene-3-carboxylic acid ethyl ester → 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (195250-44-3)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃;

DOI:10.1021/jm020180i

Reference yield:

1-(4-nitrophenyl)propan-2-one (5332-96-7) → 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (195250-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NH₄OAc; AcOH / toluene / 20 h / Heating

1.2: 67 percent / sulfur / ethanol / 2 h / 65 °C

2.1: pyridine / 45 °C

3.1: NaOMe / methanol / 20 °C

With pyridine; ammonium acetate; sodium methylate; acetic acid; In methanol; toluene;

DOI:10.1021/jm020180i

Reference yield: 84.0%

2,6-difluorobenzyl chloride (697-73-4) + 3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (195250-44-3) → 1-(2,6-difluorobenzyl)-3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (181817-72-1)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm020180i

upstream raw materials:

1-(4-nitrophenyl)propan-2-one

Downstream raw materials:

1-(2,6-difluorobenzyl)-3-(3-methoxyphenyl)-5-methyl-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

5-[(benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-6-(4-methylamino-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

6-(4-amino-phenyl)-5-[(benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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