5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:181817-09-4
Molecular Formula:C₃₆H₃₀F₂N₄O₄S
Molecular Weight:652.721
Hs Code.:

Synonyms:5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 8 articles about 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 64-18-6
formic acid

: 181816-72-8
5-[(benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-6-(4-nitro-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

: 181817-88-9
6-(4-amino-phenyl)-5-[(benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-3-(3-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

: 181817-09-4
5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 10 percent Pd/C; at 20 ℃; for 2h; atmospheric pressure;
DOI:10.1021/jm020180i

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 181817-09-4
5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / KI; K₂CO₃ / dimethylformamide / 20 °C

2: NBS; AIBN / chlorobenzene / 90 °C

3: i-Pr₂NEt / dimethylformamide / 20 °C

4: 11 percent / 10 percent Pd/C / 2 h / 20 °C / atmospheric pressure

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C; In N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/jm020180i

Reference yield:

: 5332-96-7
1-(4-nitrophenyl)propan-2-one

: 181817-09-4
5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-formylaminophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: NH₄OAc; AcOH / toluene / 20 h / Heating

1.2: 67 percent / sulfur / ethanol / 2 h / 65 °C

2.1: pyridine / 45 °C

3.1: NaOMe / methanol / 20 °C

4.1: 84 percent / KI; K₂CO₃ / dimethylformamide / 20 °C

5.1: NBS; AIBN / chlorobenzene / 90 °C

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

7.1: 11 percent / 10 percent Pd/C / 2 h / 20 °C / atmospheric pressure

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonium acetate; sodium methylate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C; In methanol; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm020180i