2-([1,1'-BIPHENYL]-4-YLOXY)ETHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-([1,1'-BIPHENYL]-4-YLOXY)ETHYLAMINE HYDROCHLORIDE
• CAS No.: 125470-84-0
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.279
• Mol file: 125470-84-0.mol

Synonyms:2-([1,1'-biphenyl]-4-yloxy)ethan-1-amine

Chemical Property of 2-([1,1'-BIPHENYL]-4-YLOXY)ETHYLAMINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 370.1±35.0 °C(Predicted)
• PKA: 8.67±0.10(Predicted)
• Density: 1.072±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-(4-phenylphenoxy)ethanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-([1,1'-BIPHENYL]-4-YLOXY)ETHYLAMINE HYDROCHLORIDE

There total 3 articles about 2-([1,1'-BIPHENYL]-4-YLOXY)ETHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H17NO3 → 2-([1,1'-biphenyl]-4-yloxy)ethan-1-amine (125470-84-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 50 ℃; for 4h;

DOI:10.1021/acsmedchemlett.6b00330

Reference yield:

4-Phenylphenol (92-69-3) → 2-([1,1'-biphenyl]-4-yloxy)ethan-1-amine (125470-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 4 h / 50 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/acsmedchemlett.6b00330

Reference yield:

biphenyl-4-yloxy-acetic acid amide (77529-40-9) → 2-([1,1'-biphenyl]-4-yloxy)ethan-1-amine (125470-84-0)

Guidance literature:

With diethylene glycol dimethyl ether; diborane;

DOI:10.1016/j.bmcl.2010.01.030

upstream raw materials:

biphenyl-4-yloxy-acetic acid amide

4-Phenylphenol

Downstream raw materials:

C₃₀H₂₉NO₃