77529-40-9Relevant academic research and scientific papers
Discovery of a new series of 5-HT1A receptor agonists
Franchini, Silvia,Prandi, Adolfo,Sorbi, Claudia,Tait, Annalisa,Baraldi, Annamaria,Angeli, Piero,Buccioni, Michela,Cilia, Antonio,Poggesi, Elena,Fossa, Paola,Brasili, Livio
scheme or table, p. 2017 - 2020 (2010/07/07)
Starting from compounds previously identified as α1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have high potency and/or high selectivity. Of these, compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting.
Revolutionizing resin handling for combinatorial synthesis
Atrash, Butrus
, p. 938 - 941 (2007/10/03)
A new resin support generated by co-sintering resin beads with an inert polymer (see picture) facilitates resin handling. A wide range of reactions was carried out to demonstrate its applicability and its comparability to the free resin.
