(4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

Base Information

Chemical Name:(4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone
CAS No.:321851-53-0
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:(4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

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Chemical Property of (4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

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Technology Process of (4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

There total 4 articles about (4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 245351-07-9
(4S)-3-[(2R,3R)-3-(N-benzoyloxy-N-benzylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

: 321851-53-0
(4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: (4S)-3-[(2R,3R)-3-(N-benzoyloxy-N-benzylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone; With hydrogen; palladium on activated charcoal; In acetic acid; at 20 ℃; for 12h;

benzyl chloroformate; With sodium hydrogencarbonate; In tetrahydrofuran; water; for 0.5h;
DOI:10.1246/bcsj.73.2423

Reference yield:

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

: 321851-53-0
(4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 0.5 h / -70 °C

2.1: CH₂Cl₂ / 1 h / -78 °C

3.1: H₂ / Pd/C / acetic acid / 12 h / 20 °C

3.2: 75 percent / NaHCO₃ / tetrahydrofuran; H₂O / 0.5 h

With hydrogen; palladium on activated charcoal; In dichloromethane; acetic acid;
DOI:10.1246/bcsj.73.2423

Reference yield:

: N-benzoyloxy-N-benzylidenebenzylammonium chloride

: 321851-53-0
(4S)-3-[(2R,3R)-3-(N-benzyloxycarbonylamino)-2-methyl-3-phenylpropionyl]-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 1 h / -78 °C

2.1: H₂ / Pd/C / acetic acid / 12 h / 20 °C

2.2: 75 percent / NaHCO₃ / tetrahydrofuran; H₂O / 0.5 h

With hydrogen; palladium on activated charcoal; In dichloromethane; acetic acid;
DOI:10.1246/bcsj.73.2423