(E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

Chemical Name:(E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS No.:1311201-36-1
Molecular Formula:C₁₇H₂₀O₅
Molecular Weight:304.343
Hs Code.:

Synonyms:(E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Technology Process of (E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 6 articles about (E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1311201-35-0
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1311201-36-1
(E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: With potassium fluoride; pyridine hydrogenfluoride; In acetone; at 25 - 28 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201100772

Reference yield:

: (E)-2-(2-(3-hydroxyprop-1-enyl)phenyl)acetonitrile

: 1311201-36-1
(E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; potassium hydroxide / 13 h / 100 °C / Inert atmosphere

2.1: 1H-imidazole / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 25 - 28 °C / Inert atmosphere

2.3: 0 °C / pH Ca_. 6 / Inert atmosphere

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 °C / Inert atmosphere

3.2: 24 h / 0 °C / Inert atmosphere

4.1: potassium fluoride; pyridine hydrogenfluoride / acetone / 1 h / 25 - 28 °C / Inert atmosphere

With 1H-imidazole; dmap; potassium fluoride; water; pyridine hydrogenfluoride; dicyclohexyl-carbodiimide; potassium hydroxide; In hexane; dichloromethane; acetone;
DOI:10.1002/anie.201100772

Reference yield:

: 1311201-33-8
(E)-2-(2-(3-hydroxyprop-1-enyl)phenyl)acetic acid

: 1311201-36-1
(E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 25 - 28 °C / Inert atmosphere

1.3: 0 °C / pH Ca_. 6 / Inert atmosphere

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 °C / Inert atmosphere

3.1: potassium fluoride; pyridine hydrogenfluoride / acetone / 1 h / 25 - 28 °C / Inert atmosphere

With 1H-imidazole; dmap; potassium fluoride; pyridine hydrogenfluoride; dicyclohexyl-carbodiimide; In hexane; dichloromethane; acetone;
DOI:10.1002/anie.201100772