(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

Chemical Name:(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS No.:1311201-35-0
Molecular Formula:C₂₃H₃₄O₅Si
Molecular Weight:418.605
Hs Code.:

Synonyms:(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Chemical Property of (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Technology Process of (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 5 articles about (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2033-24-1
cycl-isopropylidene malonate

: 1311201-34-9
(E)-2-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenyl)acetic acid

: 1311201-35-0
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: cycl-isopropylidene malonate; (E)-2-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenyl)acetic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

With sodium tetrahydroborate; acetic acid; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.201100772

Reference yield:

: (E)-2-(2-(3-hydroxyprop-1-enyl)phenyl)acetonitrile

: 1311201-35-0
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; potassium hydroxide / 13 h / 100 °C / Inert atmosphere

2.1: 1H-imidazole / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 25 - 28 °C / Inert atmosphere

2.3: 0 °C / pH Ca_. 6 / Inert atmosphere

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 °C / Inert atmosphere

3.2: 24 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; water; dicyclohexyl-carbodiimide; potassium hydroxide; In hexane; dichloromethane;
DOI:10.1002/anie.201100772

Reference yield:

: (E)-3-(2-(bromomethyl)phenyl)prop-2-en-1-ol

: 1311201-35-0
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 5 h / Reflux; Inert atmosphere

2.1: water; potassium hydroxide / 13 h / 100 °C / Inert atmosphere

3.1: 1H-imidazole / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 25 - 28 °C / Inert atmosphere

3.3: 0 °C / pH Ca_. 6 / Inert atmosphere

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 °C / Inert atmosphere

4.2: 24 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; water; dicyclohexyl-carbodiimide; potassium hydroxide; In ethanol; hexane; dichloromethane;
DOI:10.1002/anie.201100772