Technology Process of (2R,3S)-N-benzoyl-O-<(benzyloxy)methyl>-3-phenylisoserine methyl ester
There total 5 articles about (2R,3S)-N-benzoyl-O-<(benzyloxy)methyl>-3-phenylisoserine methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 40h;
DOI:10.1021/jo00351a008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / azidotrimethylsilane, zinc chloride / 48 h / 68 °C
2: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 1 h
3: 1.) H2 / 1.) 10percent Pd/C / 1.) CH3OH, 15 h, 2.) CH3OH, RT, 72 h
4: 75 percent / ethyldiisopropylamine / CH2Cl2 / 40 h
With
dmap; trimethylsilylazide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride;
palladium on activated charcoal;
In
dichloromethane;
DOI:10.1021/jo00351a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium bicarbonate, sodium periodate, ruthenium trichloride trihydrate / 1.) CCl4, acetonitrile, water, 20 deg C, 44 h, 2.) Et2O
2: 90 percent / azidotrimethylsilane, zinc chloride / 48 h / 68 °C
3: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 1 h
4: 1.) H2 / 1.) 10percent Pd/C / 1.) CH3OH, 15 h, 2.) CH3OH, RT, 72 h
5: 75 percent / ethyldiisopropylamine / CH2Cl2 / 40 h
With
dmap; ruthenium trichloride; sodium periodate; trimethylsilylazide; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride;
palladium on activated charcoal;
In
dichloromethane;
DOI:10.1021/jo00351a008
