6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

Base Information

Chemical Name:6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one
CAS No.:1036403-22-1
Molecular Formula:C₂₂H₁₇BrFN₃O₂
Molecular Weight:454.298
Hs Code.:

Synonyms:6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

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Chemical Property of 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

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Technology Process of 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

There total 2 articles about 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1036402-39-7
8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

: 1036403-22-1
6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

Guidance literature:: 8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

Benzyloxymethyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 78239-71-1
3-bromo-4-fluorobenzyl bromide

: 1036403-22-1
6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / diethyl ether / Reflux; Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: hydrazine / ethanol / 5 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With potassium tert-butylate; iodine; magnesium; hydrazine; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 930-21-2
2-azetidinone

: 1036403-22-1
6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

: C₂₅H₂₁FN₄O₃

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 200 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.bmc.2012.06.021