8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one

Base Information

• Chemical Name: 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one
• CAS No.: 1036403-05-0
• Molecular Formula: C₁₇H₁₇FN₄O₂
• Molecular Weight: 328.346
• Mol file: 1036403-05-0.mol

Synonyms:8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one

Chemical Property of 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one

There total 5 articles about 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H21FN4O3 → 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one (1036403-05-0)

Guidance literature:

With hydrogenchloride; platinum on carbon; 5 % Pd(OH)2 on carbon; hydrogen; In water; N,N-dimethyl-formamide; at 20 ℃; for 48h; under 2068.65 Torr; Inert atmosphere;

DOI:10.1016/j.bmc.2012.06.021

Reference yield:

6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one (1036403-22-1) → 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one (1036403-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 200 °C / Microwave irradiation; Inert atmosphere

2: hydrogenchloride; platinum on carbon; 5 % Pd(OH)2 on carbon; hydrogen / water; N,N-dimethyl-formamide / 48 h / 20 °C / 2068.65 Torr / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; platinum on carbon; 5 % Pd(OH)2 on carbon; hydrogen; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.06.021

Reference yield:

8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one (1036402-39-7) → 8-(4-fluoro-3-(2-oxoazetidin-1-yl)benzyl)-1,2,3,4-tetrahydropyrido[3,2-d]pyridazin-5(6H)-one (1036403-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 200 °C / Microwave irradiation; Inert atmosphere

3.1: hydrogenchloride; platinum on carbon; 5 % Pd(OH)2 on carbon; hydrogen / water; N,N-dimethyl-formamide / 48 h / 20 °C / 2068.65 Torr / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; platinum on carbon; 5 % Pd(OH)2 on carbon; potassium tert-butylate; hydrogen; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.06.021

upstream raw materials:

6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

3-bromo-4-fluorobenzyl bromide