Technology Process of benzyl 5-(3,4-dichlorophenyl)-3-methoxy-3-(methoxymethyl)-2,3,4,7-tetrahydro-1H-azepin-1-carboxylate
There total 4 articles about benzyl 5-(3,4-dichlorophenyl)-3-methoxy-3-(methoxymethyl)-2,3,4,7-tetrahydro-1H-azepin-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver tetrafluoroborate; (triphenyl phosphite)gold(I) chloride;
In
methanol; dichloromethane;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1002/chem.201101346
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
3: silver tetrafluoroborate; (triphenyl phosphite)gold(I) chloride / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver tetrafluoroborate; (triphenyl phosphite)gold(I) chloride; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2: Sonogashira coupling;
DOI:10.1002/chem.201101346
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydrogencarbonate / ethanol; water / 14 h / 0 - 20 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
4: silver tetrafluoroborate; (triphenyl phosphite)gold(I) chloride / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver tetrafluoroborate; (triphenyl phosphite)gold(I) chloride; sodium hydride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
3: Sonogashira coupling;
DOI:10.1002/chem.201101346
