dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

Base Information

Chemical Name:dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate
CAS No.:1430843-67-6
Molecular Formula:C₂₀H₁₈F₃NO₄
Molecular Weight:393.362
Hs Code.:

Synonyms:dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

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Chemical Property of dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

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Technology Process of dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

There total 4 articles about dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430843-63-2
3-benzyl-7-trifluoromethyl-1H,3H-pyrrolo[1,2-c]thiazole-2,2-dioxide

: 1430843-66-5
dimethyl 3-benzyl-5-methyl-6-trifluoromethyl-3H-pyrrolizine-1,2-dicarboxylate

: 1430843-67-6
dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

Guidance literature:: With 1,2,4-Trichlorobenzene; at 240 ℃; for 0.166667h; Overall yield = 44 %; Microwave irradiation;
DOI:10.1016/j.tet.2013.03.017

Reference yield:

: 50739-30-5
2-benzyl-1,3-thiazolidine-4-carboxylic acid

: 1430843-66-5
dimethyl 3-benzyl-5-methyl-6-trifluoromethyl-3H-pyrrolizine-1,2-dicarboxylate

: 1430843-67-6
dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 24 h / 60 °C

2: dichloromethane / 8 h / 0 - 20 °C

3: sodium tungstate (VI) dihydrate; phenylphosphonate; Aliquat 336; dihydrogen peroxide / ethyl acetate; water / 144 h / 40 °C

4: 1,2,4-Trichlorobenzene / 0.17 h / 240 °C / Microwave irradiation

With sodium tungstate (VI) dihydrate; phenylphosphonate; dihydrogen peroxide; Aliquat 336; 1,2,4-Trichlorobenzene; In dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2013.03.017

Reference yield:

: 1430843-61-0
(2R,4R)-2-benzyl-3-[(E)-4,4,4-trifluoro-3-oxobut-1-enyl]thiazolidine-4-carboxylic acid

: 1430843-66-5
dimethyl 3-benzyl-5-methyl-6-trifluoromethyl-3H-pyrrolizine-1,2-dicarboxylate

: 1430843-67-6
dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 8 h / 0 - 20 °C

2: sodium tungstate (VI) dihydrate; phenylphosphonate; Aliquat 336; dihydrogen peroxide / ethyl acetate; water / 144 h / 40 °C

3: 1,2,4-Trichlorobenzene / 0.17 h / 240 °C / Microwave irradiation

With sodium tungstate (VI) dihydrate; phenylphosphonate; dihydrogen peroxide; Aliquat 336; 1,2,4-Trichlorobenzene; In dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tet.2013.03.017