50739-30-5

Usage

InChI:InChI=1/C11H13NO2S/c13-11(14)9-7-15-10(12-9)6-8-4-2-1-3-5-8/h1-5,9-10,12H,6-7H2,(H,13,14)/t9-,10?/m1/s1

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 122-78-1 phenylacetaldehyde 
• 52-90-4 L-Cysteine 
• 29969-69-5 3,3-diethoxy-2-phenyl-propionic acid 
• 59216-85-2 α-formyl phenyl acetic acid 

Downstream Products

• 864236-19-1 dimethyl 3-benzyl-5-methyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate 
• 1041643-83-7 C₁₆H₂₁NO₄S 
• 1430843-66-5 dimethyl 3-benzyl-5-methyl-6-trifluoromethyl-3H-pyrrolizine-1,2-dicarboxylate 
• 1430843-67-6 dimethyl 5-benzyl-1-trifluoromethyl-5,8-dihydroindolizine-6,7-dicarboxylate 
• 1430843-65-4 2-methyl-1-styryl-3-trifluoromethyl-1H-pyrrole 
• 1430843-64-3 C₁₄H₁₂F₃N 
• 1430843-63-2 3-benzyl-7-trifluoromethyl-1H,3H-pyrrolo[1,2-c]thiazole-2,2-dioxide 
• 1430843-61-0 (2R,4R)-2-benzyl-3-[(E)-4,4,4-trifluoro-3-oxobut-1-enyl]thiazolidine-4-carboxylic acid 

Relevant academic research and scientific papers

Discovery of cysteine and its derivatives as novel antiviral and antifungal agents

Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by1 H-NMR,13 C-NMR, and

GLUCOSE-SENSITIVE PEPTIDE HORMONES

The present invention relates to a conjugate of the formula P-L-I, wherein P is a peptide hormone effecting the metabolism of carbohydrates in vivo, L is a hydrolysable linker molecule consisting of Lp and Lj, and I is a molecule capable of inhibiting the effect of the peptide hormone P on the metabolism of carbohydrates in vivo. Under in vivo conditions, the conjugate is the major compound. When the concentration of glucose increases in v/vo,the concentration of the peptide hormone effecting the metabolism of carbohydrates in vivo also increases.

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma

We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.

Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer

To improve the selectivity and antiproliferative activity of previously reported serine amide phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4-thiazolidinone moiety was introduced as a phosphate mimic. However, these 4-thiazolidinone derivatives demonstrated less cytotoxicity in prostate cancer cells despite improved selectivity over RH7777 cells. To further optimize the thiazolidinone analogues in terms of cytotoxicity and selectivity, we made closely related structural modifications, which led us to the discovery of a new class of 2-arylthiazolidine-4-carboxylic acid amides. These compounds were potent cytotoxic agents with IC50 values in the low micromolar concentration range and demonstrated enhanced selectivity in receptor-negative cells compared to SAPs and 4-thiazolidinone amides.