(S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester

Base Information

• Chemical Name: (S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester
• CAS No.: 906356-19-2
• Molecular Formula: C₂₈H₃₀INO₅
• Molecular Weight: 587.454
• Mol file: 906356-19-2.mol

Synonyms:(S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester

Chemical Property of (S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester

There total 3 articles about (S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl bromide (100-39-0) + N-tert-butyloxycarbonyl-3-iodo-L-tyrosine (71400-63-0,478183-68-5) → (S)-Nα-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester (906356-19-2)

Guidance literature:

With sodium carbonate; In acetone; at 20 ℃; for 5h;

DOI:10.1021/jo060704c

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-Nα-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester (906356-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N / H₂O; dioxane / 18.75 h / 0 - 20 °C

2: 93 percent / Na₂CO₃ / acetone / 5 h / 20 °C

With sodium carbonate; triethylamine; In 1,4-dioxane; water; acetone;

DOI:10.1021/jo060704c

Reference yield:

3-Iodo-L-tyrosine (70-78-0) → (S)-Nα-tert-butyloxycarbonyl-O-benzyl-m-iodotyrosine benzyl ester (906356-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N / H₂O; dioxane / 18.75 h / 0 - 20 °C

2: 93 percent / Na₂CO₃ / acetone / 5 h / 20 °C

With sodium carbonate; triethylamine; In 1,4-dioxane; water; acetone;

DOI:10.1021/jo060704c

upstream raw materials:

benzyl bromide

N-tert-butyloxycarbonyl-3-iodo-L-tyrosine

di-tert-butyl dicarbonate

3-Iodo-L-tyrosine

Downstream raw materials:

benzyl (S)-3-(6-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-(((benzyloxy)carbonyl)amino)propanoate

(S)-N^α-tert-butyloxycarbonyl-O-benzyl-m-(o-tolyl)tyrosine benzyl ester