4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide
• CAS No.: 1380543-96-3
• Molecular Formula: C₁₇H₂₈N₂O₂S
• Molecular Weight: 324.488
• Mol file: 1380543-96-3.mol

Synonyms:4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide

Chemical Property of 4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide

There total 2 articles about 4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pyrrolidine (123-75-1) + 2-butyl-N-tosylaziridine (116905-61-4) → 4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide (1380543-96-3)

Guidance literature:

With tributylphosphine; In water; acetonitrile; for 1h; regioselective reaction; Inert atmosphere; Reflux;

DOI:10.1016/j.cclet.2012.04.003

Reference yield: 78.0%

pyrrolidine (123-75-1) + 1-hexene (592-41-6,25067-06-5) + 4-methyl-N-(pivaloyloxy)benzenesulfonamide → 4-methyl-N-[1-(pyrrolidin-1-yl)hexan-2-yl]benzenesulfonamide (1380543-96-3)

Guidance literature:

1-hexene; 4-methyl-N-(pivaloyloxy)benzenesulfonamide; With [(η(5)-heptamethylindenyl)RhCl(μ-Cl)]2; caesium carbonate; at 22 ℃; for 16h;

pyrrolidine; at 80 ℃; for 20h; regioselective reaction;

DOI:10.1055/s-0039-1690756

upstream raw materials:

pyrrolidine

2-butyl-N-tosylaziridine

1-hexene