1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

Base Information

• Chemical Name: 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile
• CAS No.: 82980-13-0
• Molecular Formula: C₂₄H₂₅N₃O₂S
• Molecular Weight: 419.547
• Mol file: 82980-13-0.mol

Synonyms:1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

Chemical Property of 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

There total 5 articles about 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<β-(3-indolyl)ethyl>-3-ethylpyridinium bromide (24716-24-3) → 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile (82980-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) sodium borohydride, 2.) tetrabutylammonium hydrogen sulfate, 50percent NaOH / 1.) MeOH, RT, 1 h, 2.) benzene, RT, 1 h

2: 96 percent / m-chloroperbenzoic acid, sodium bicarbonate / CH₂Cl₂; H₂O / 1 h / Ambient temperature

3: CH₂Cl₂ / 1 h / 0 °C

4: sodium acetate / CH₂Cl₂; H₂O / 0.5 h / Ambient temperature; pH 4

With sodium hydroxide; sodium tetrahydroborate; sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

DOI:10.1021/jo00144a009

Reference yield:

1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole (82980-11-8) → 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile (82980-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 0 °C

2: sodium acetate / CH₂Cl₂; H₂O / 0.5 h / Ambient temperature; pH 4

With sodium acetate; In dichloromethane; water;

DOI:10.1021/jo00144a009

Reference yield:

1-(Phenylsulfonyl)-3-<2-(5-ethyl-1,2,3,6-tetrahydropyrid-1-yl)ethyl>indole (82980-08-3) → 1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile (82980-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / m-chloroperbenzoic acid, sodium bicarbonate / CH₂Cl₂; H₂O / 1 h / Ambient temperature

2: CH₂Cl₂ / 1 h / 0 °C

3: sodium acetate / CH₂Cl₂; H₂O / 0.5 h / Ambient temperature; pH 4

With sodium acetate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

DOI:10.1021/jo00144a009

upstream raw materials:

potassium cyanide

N-<β-(3-indolyl)ethyl>-3-ethylpyridinium bromide

1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole

1-(Phenylsulfonyl)-3-<2-(5-ethyl-1,2,3,6-tetrahydropyrid-1-yl)ethyl>indole

Downstream raw materials:

2-{1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-5-ethyl-1,2,3,4-tetrahydro-pyridin-4-yl}-malonic acid dimethyl ester

2-{(2S,3S,4S)-1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-2-cyano-3-ethyl-piperidin-4-yl}-malonic acid dimethyl ester

2-{(2S,3R,4S)-1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-2-cyano-3-ethyl-piperidin-4-yl}-malonic acid dimethyl ester