1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole

Base Information

• Chemical Name: 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole
• CAS No.: 82980-11-8
• Molecular Formula: C₂₃H₂₆N₂O₃S
• Molecular Weight: 410.537
• Mol file: 82980-11-8.mol

Synonyms:1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole

Chemical Property of 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole

There total 3 articles about 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(Phenylsulfonyl)-3-<2-(5-ethyl-1,2,3,6-tetrahydropyrid-1-yl)ethyl>indole (82980-08-3) → 3-ethenyl-1-phenylsulfonyl-1H-indole (82980-12-9) + 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole (82980-11-8)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; for 1h; Ambient temperature;

DOI:10.1021/jo00144a009

Reference yield:

N-<β-(3-indolyl)ethyl>-3-ethylpyridinium bromide (24716-24-3) → 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole (82980-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium borohydride, 2.) tetrabutylammonium hydrogen sulfate, 50percent NaOH / 1.) MeOH, RT, 1 h, 2.) benzene, RT, 1 h

2: 96 percent / m-chloroperbenzoic acid, sodium bicarbonate / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

DOI:10.1021/jo00144a009

Reference yield:

benzenesulfonyl chloride (98-09-9) → 1-Benzenesulfonyl-3-[2-(5-ethyl-1-oxy-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-1H-indole (82980-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium borohydride, 2.) tetrabutylammonium hydrogen sulfate, 50percent NaOH / 1.) MeOH, RT, 1 h, 2.) benzene, RT, 1 h

2: 96 percent / m-chloroperbenzoic acid, sodium bicarbonate / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

DOI:10.1021/jo00144a009

upstream raw materials:

1-(Phenylsulfonyl)-3-<2-(5-ethyl-1,2,3,6-tetrahydropyrid-1-yl)ethyl>indole

N-<β-(3-indolyl)ethyl>-3-ethylpyridinium bromide

benzenesulfonyl chloride

Downstream raw materials:

1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-3-ethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

2-{1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-5-ethyl-1,2,3,4-tetrahydro-pyridin-4-yl}-malonic acid dimethyl ester

2-{(2S,3R,4S)-1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-2-cyano-3-ethyl-piperidin-4-yl}-malonic acid dimethyl ester

2-{(2S,3S,4S)-1-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-2-cyano-3-ethyl-piperidin-4-yl}-malonic acid dimethyl ester