1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

Base Information

Chemical Name:1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate
CAS No.:477352-24-2
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

Chemical Property:

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Technology Process of 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

There total 2 articles about 1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 64-17-5
ethanol

: 477352-23-1
C₂₀H₂₀N₂O

: 477352-24-2
1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

Guidance literature:: With sulfuric acid; water; for 19h; Reflux;
DOI:10.1016/j.bmc.2011.11.002

Reference yield:

: 398476-50-1
C₂₀H₂₃NO₂

: 477352-24-2
1'-tert-butyl 3-ethyl 1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1',3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / tetracyanoethylene / acetonitrile / Heating

2: 39 percent / aq. H₂SO₄ / 7.5 h / Heating

With sulfuric acid; ethenetetracarbonitrile; In acetonitrile;
DOI:10.1021/jm020889p