D-cis-4,5-methanoprolineamide methanesulfonic acid salt

Base Information

Chemical Name:D-cis-4,5-methanoprolineamide methanesulfonic acid salt
CAS No.:1312338-82-1
Molecular Formula:CH₄O₃S*C₆H₁₀N₂O
Molecular Weight:222.265
Hs Code.:

Synonyms:D-cis-4,5-methanoprolineamide methanesulfonic acid salt

Suppliers and Price of D-cis-4,5-methanoprolineamide methanesulfonic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of D-cis-4,5-methanoprolineamide methanesulfonic acid salt

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of D-cis-4,5-methanoprolineamide methanesulfonic acid salt

There total 1 articles about D-cis-4,5-methanoprolineamide methanesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1312338-82-1
D-cis-4,5-methanoprolineamide methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1: dmap

2: lithium triethylborohydride / toluene / -70 - -60 °C

3: dmap; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine

4: water; lithium hydroxide / ethanol

5: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran

6: diethylzinc / 1,2-dimethoxyethane; dichloromethane / -30 - 20 °C

7: isopropyl alcohol / 60 °C

With dmap; ammonia; water; diethylzinc; lithium triethylborohydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; isopropyl alcohol; toluene; 6: |Simmons-Smith Cyclopropanation;
DOI:10.1016/j.bmc.2013.12.061

Reference yield: 79.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1312338-82-1
D-cis-4,5-methanoprolineamide methanesulfonic acid salt

: 197142-34-0
(1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

Guidance literature:: D-cis-4,5-methanoprolineamide methanesulfonic acid salt; With sodium ethanolate; In ethanol; isopropyl alcohol; at 50 ℃; for 1h;

With water; In ethanol; isopropyl alcohol; at 60 ℃; for 18h;

di-tert-butyl dicarbonate; In ethanol; water; isopropyl alcohol;

Reference yield:

: 1312338-82-1
D-cis-4,5-methanoprolineamide methanesulfonic acid salt

: 1180671-56-0
(1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / isopropyl alcohol; ethanol / 1 h / 50 °C

1.2: 18 h / 60 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2.2: 3 h / 140 °C / Sealed vessel

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In ethanol; isopropyl alcohol; acetonitrile;