Technology Process of (4R,5R)-benzyl 5-fluoro-4-hydroxyhexanoate
There total 6 articles about (4R,5R)-benzyl 5-fluoro-4-hydroxyhexanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
at 20 ℃;
for 16h;
In
N,N-dimethyl-formamide;
for 16h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanesulfonamide; AD-mix β / tert-butyl alcohol; water / 96 h / 4 °C
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C / Inert atmosphere
3.1: potassium hydroxide / ethanol / 2 h / 60 °C
3.2: 24 h / 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 24.5 h / -78 - 20 °C
5.1: potassium hydroxide; methanol / 16 h / 20 °C
6.1: N,N-dimethyl-formamide / 16 h
With
methanol; methanesulfonamide; di-isopropyl azodicarboxylate; AD-mix β; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate; potassium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
2.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.12.009
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hydroxide; methanol / 16 h / 20 °C
2: N,N-dimethyl-formamide / 16 h
With
methanol; potassium hydroxide;
In
N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.12.009
