Technology Process of C18H16F2O3
There total 9 articles about C18H16F2O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silver(I) nitrite; sodium hydroxide;
In
ethanol; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere; Sealed
2.1: potassium hydroxide / diethyl ether; water / 0.03 h / 0 °C
2.2: 4 h / 0 - 5 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran
7.1: hydrogenchloride / water
8.1: water; silver(I) nitrite / ethanol
With
hydrogenchloride; lithium aluminium tetrahydride; silver(I) nitrite; oxalyl dichloride; water; potassium carbonate; dimethyl sulfoxide; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; lithium hexamethyldisilazane;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
5.1: Swern Oxidation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
2: lithium hexamethyldisilazane / tetrahydrofuran
3: hydrogenchloride / water
4: water; silver(I) nitrite / ethanol
With
hydrogenchloride; silver(I) nitrite; oxalyl dichloride; water; dimethyl sulfoxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane; water;
1: Swern Oxidation;
