2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester
CAS No.:1224103-65-4
Molecular Formula:C₁₉H₁₈F₂O₃
Molecular Weight:332.347
Hs Code.:

Synonyms:2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

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Chemical Property of 2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

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Technology Process of 2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

There total 9 articles about 2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1609289-02-2
(E)-3-(4-benzyloxy-3,5-difluorophenyl)acrylic acid ethyl ester

: 1224103-65-4
2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With palladium diacetate; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 5h;

Reference yield:

: 1224103-64-3
2-(3,5-difluoro-4-hydroxyphenyl)cyclopropanecarboxylic acid ethyl ester

: 100-39-0
benzyl bromide

: 1224103-65-4
2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1224103-65-4
2-(4-benzyloxy-3,5-difluorophenyl)cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere; Sealed

2.1: potassium hydroxide / diethyl ether; water / 0.03 h / 0 °C

2.2: 4 h / 0 - 5 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; palladium diacetate; In diethyl ether; water; N,N-dimethyl-formamide;