1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione
• CAS No.: 215500-24-6
• Molecular Formula: C₄₀H₄₈N₂O₇Si
• Molecular Weight: 696.916
• Mol file: 215500-24-6.mol

Synonyms:1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione

There total 5 articles about 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine (80971-33-1) + propargyl bromide (106-96-7) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione (215500-24-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1080/07328319808004722

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione (215500-24-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine, DMAP

2: imidazole / dimethylformamide

3: 95 percent / K₂CO₃ / dimethylformamide

With pyridine; 1H-imidazole; dmap; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1080/07328319808004722

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-3-prop-2-ynyl-1H-pyrimidine-2,4-dione (215500-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: 95 percent / K₂CO₃ / dimethylformamide

With 1H-imidazole; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1080/07328319808004722

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

propargyl bromide

4,4'-dimethoxytrityl chloride

tert-butyldimethylsilyl chloride