methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate

Base Information

• Chemical Name: methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate
• CAS No.: 66670-11-9
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321

Synonyms:methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate

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Chemical Property of methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate

There total 2 articles about methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl β,β'-(2-phenylethylamino)dipropionate (38129-46-3) → methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate (66670-11-9)

Guidance literature:

With sodium hydride; In benzene; at 70 ℃; for 1.5h;

DOI:10.1111/j.2042-7158.1995.tb05765.x

Reference yield:

phenethylamine (64-04-0) → methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate (66670-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / Reflux

2: sodium; methanol / toluene / Reflux

With methanol; sodium; acetic acid; In methanol; toluene; 1: |Michael Addition / 2: |Dieckmann Condensation;

DOI:10.1002/jhet.916

Reference yield:

methyl 1-(2-phenylethyl)-4-oxo-piperidine-3-carboxylate (66670-11-9) → 1-(2-phenylethyl)-4-piperidinone (39742-60-4)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1016/j.molstruc.2009.04.008

upstream raw materials:

dimethyl β,β'-(2-phenylethylamino)dipropionate

phenethylamine

Downstream raw materials:

1-(2-phenylethyl)-4-piperidinone

1-(2-phenylethyl)-4-aminomethyl-4-piperidinol