(1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

Base Information

Chemical Name:(1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate
CAS No.:289051-67-8
Molecular Formula:C₃₃H₄₆NO₆PSi
Molecular Weight:611.791
Hs Code.:

Synonyms:(1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

Chemical Property:

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Technology Process of (1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

There total 7 articles about (1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 526217-41-4
Phosphoric acid dibenzyl ester (1R,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-octanoylamino-2-phenyl-ethyl ester

: 289051-67-8
(1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 5.5h;
DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 289051-67-8
(1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 7 steps

1: 59 percent / NaN₃; NH₄Cl / dioxane; H₂O / 48 h / 80 °C

2: 6 M HCl; H₂ / 10 percent Pd/C / ethanol / 14 h / 20 °C

3: 83 percent / NaHCO₃ / tetrahydrofuran; H₂O / 7 h / 0 °C

4: 2.3 g / imidazole / dimethylformamide / 18 h / 20 °C

5: tetrazole / acetonitrile / 3 h / 20 °C

6: m-CPBA / CH₂Cl₂ / 1 h / 0 °C

7: H₂ / 10 percent Pd/C / methanol / 5.5 h / 20 °C

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

: 121745-57-1
(2R,3R)-3-azido-3-phenyl-propane-1,2diol

: 289051-67-8
(1R,2R)-1-tert-butyldiphenylsilyloxymethyl-2-octanoylamino-2-phenylethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 6 steps

1: 6 M HCl; H₂ / 10 percent Pd/C / ethanol / 14 h / 20 °C

2: 83 percent / NaHCO₃ / tetrahydrofuran; H₂O / 7 h / 0 °C

3: 2.3 g / imidazole / dimethylformamide / 18 h / 20 °C

4: tetrazole / acetonitrile / 3 h / 20 °C

5: m-CPBA / CH₂Cl₂ / 1 h / 0 °C

6: H₂ / 10 percent Pd/C / methanol / 5.5 h / 20 °C

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; hydrogen; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(02)00380-2