tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate
CAS No.:1464153-55-6
Molecular Formula:C₃₂H₃₄N₆O₃
Molecular Weight:550.66
Hs Code.:

Synonyms:tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

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Chemical Property of tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

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Technology Process of tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

There total 4 articles about tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1464153-62-5
4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoic acid

: 165528-81-4
tert-butyl 2-(piperidin-4-yl)ethylcarbamate

: 1464153-55-6
tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1245644-42-1
6-bromo-3-iodo-imidazo[1,2-a]pyrazine

: 1464153-55-6
tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; N,N-dimethyl-formamide / 1 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 12 h / 20 °C

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 126747-14-6
4-cyanophenylboronic acid

: 1464153-55-6
tert-butyl 2-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; N,N-dimethyl-formamide / 1 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 12 h / 20 °C

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;