N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

Base Information

• Chemical Name: N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester
• CAS No.: 96866-20-5
• Molecular Formula: C₂₄H₂₈N₂O₅
• Molecular Weight: 424.497
• Mol file: 96866-20-5.mol

Synonyms:N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

Chemical Property of N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

There total 4 articles about N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

O-benzylhydoxylamine hydrochloride (2687-43-6) + N-(3-carboxy-2-benzylidene-1-oxopropyl)glycine tert-butyl ester (87439-02-9) → N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester (96866-20-5)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; Ambient temperature;

DOI:10.1021/jm00147a007

Reference yield:

Glycine tert-butyl ester (6456-74-2) → N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester (96866-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N,1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 83 percent / 1 N aq. NaOH / ethanol / 2 h / Ambient temperature

3: 67 percent / Et₃N,1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1021/jm00147a007

Reference yield:

3-(ethoxycarbonyl)-2-benzylidenepropanoic acid (87439-00-7) → N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester (96866-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N,1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 83 percent / 1 N aq. NaOH / ethanol / 2 h / Ambient temperature

3: 67 percent / Et₃N,1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1021/jm00147a007

upstream raw materials:

O-benzylhydoxylamine hydrochloride

N-(3-carboxy-2-benzylidene-1-oxopropyl)glycine tert-butyl ester

Glycine tert-butyl ester

3-(ethoxycarbonyl)-2-benzylidenepropanoic acid

Downstream raw materials:

N-(N-hydroxy 3-carbamoyl 2-benzyl propanoyl)-glycine

N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine