BrC₆H₄C₃H₅O₂C₇H₆C₆H₄

Base Information

• Chemical Name: BrC₆H₄C₃H₅O₂C₇H₆C₆H₄
• CAS No.: 937795-08-9
• Molecular Formula: C₂₂H₁₉BrO₂
• Molecular Weight: 395.296
• Mol file: 937795-08-9.mol

Synonyms:BrC₆H₄C₃H₅O₂C₇H₆C₆H₄

Chemical Property of BrC₆H₄C₃H₅O₂C₇H₆C₆H₄

Chemical Property:

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Technology Process of BrC₆H₄C₃H₅O₂C₇H₆C₆H₄

There total 1 articles about BrC₆H₄C₃H₅O₂C₇H₆C₆H₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

[(2S,3S)-3-(4-bromophenyl)oxiran-2-yl]methanol (106948-05-4) + Bromodiphenylmethane (776-74-9) → BrC6H4C3H5O2C7H6C6H4 (937795-08-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at -20 - 20 ℃;

DOI:10.1021/jo062612t

Reference yield: 70.0%

BrC6H4C3H5O2C7H6C6H4 (937795-08-9) + phenylboronic acid (98-80-6) → C28H24O2 (937795-12-5)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; [Pd₂(dba)₃]*benzene; In toluene; at 100 ℃; for 3h;

DOI:10.1021/jo062612t

Reference yield:

BrC6H4C3H5O2C7H6C6H4 (937795-08-9) → C28H27NO2

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Cs₂CO₃; S-Phos / Pd₂(dba)3*C₆H₆ / toluene / 3 h / 100 °C

2: 92 percent / aq. NH₃; LiClO₄ / tetrahydrofuran / 0.75 h / 125 °C / microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; ammonium hydroxide; lithium perchlorate; caesium carbonate; [Pd₂(dba)₃]*benzene; In tetrahydrofuran; toluene; 1: Suzuki coupling;

DOI:10.1021/jo062612t

upstream raw materials:

[(2S,3S)-3-(4-bromophenyl)oxiran-2-yl]methanol

Bromodiphenylmethane

Downstream raw materials:

C₂₈H₂₄O₂