phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate

Base Information

• Chemical Name: phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate
• CAS No.: 215589-49-4
• Molecular Formula: C₁₄H₁₃ClN₂O₂S
• Molecular Weight: 308.788
• Mol file: 215589-49-4.mol

Synonyms:phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate

Chemical Property of phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate

There total 3 articles about phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

phenyl chloroformate (1885-14-9) + 3-amino-2-chloro-6-methyl-4-(methylthio)pyridine (182256-64-0) → phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate (215589-49-4)

Guidance literature:

With N,N-dimethyl-aniline; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm980399q

Reference yield:

2,4-dichloro-6-methyl-3-nitropyridine (63897-12-1) → phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate (215589-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / methanol / 5 h / Ambient temperature

2: 93 percent / H₂ / Raney-Ni / dioxane; methanol / 3 h / 760 Torr

3: 68 percent / N,N-dimethylaniline / CH₂Cl₂ / 3 h / Ambient temperature

With hydrogen; N,N-dimethyl-aniline; nickel; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm980399q

Reference yield:

2-chloro-6-methyl-4-(methylthio)-3-nitropyridine (179057-09-1) → phenyl N-<2-chloro-6-methyl-4-(methylthio)pyridin-3-yl>carbamate (215589-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / H₂ / Raney-Ni / dioxane; methanol / 3 h / 760 Torr

2: 68 percent / N,N-dimethylaniline / CH₂Cl₂ / 3 h / Ambient temperature

With hydrogen; N,N-dimethyl-aniline; nickel; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm980399q

upstream raw materials:

phenyl chloroformate

3-amino-2-chloro-6-methyl-4-(methylthio)pyridine

2,4-dichloro-6-methyl-3-nitropyridine

2-chloro-6-methyl-4-(methylthio)-3-nitropyridine

Downstream raw materials:

3-(2-chloro-6-methyl-4-methylsulfanyl-pyridin-3-yl)-1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-urea