2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

Base Information

Chemical Name:2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide
CAS No.:1245940-86-6
Molecular Formula:C₂₄H₂₂ClF₆N₅O₄
Molecular Weight:593.913
Hs Code.:

2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

Synonyms:2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

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Chemical Property of 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

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Technology Process of 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

There total 7 articles about 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 959140-61-5
{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 2-amino-2-[3-(trifluoromethyl)phenyl]butanamide hydrochloride

: 1245940-86-6
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

Guidance literature:: {3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid; With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 0.333333h;

2-amino-2-[3-(trifluoromethyl)phenyl]butanamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 959140-59-1
methyl {3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

: 1245940-86-6
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / water; methanol / 1 h / 20 °C

1.2: pH 1 - 2

2.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.33 h

2.2: 2 h / 20 °C

With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1245940-86-6
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]butanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 20 - 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate / methanol / 1.5 h / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: ethyl acetate; 2-Methylpentane / Resolution of racemate

7.1: lithium hydroxide / water; methanol / 1 h / 20 °C

7.2: pH 1 - 2

8.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.33 h

8.2: 2 h / 20 °C

With sodium tetrahydroborate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; water; potassium carbonate; benzotriazol-1-ol; potassium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; pyridine; methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;