(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

Base Information

Chemical Name:(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol
CAS No.:126587-67-5
Molecular Formula:C₂₁H₃₈O₃Si
Molecular Weight:366.616
Hs Code.:

Synonyms:(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

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Chemical Property of (2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

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Technology Process of (2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

There total 8 articles about (2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 126587-66-4
(2R,3S,4S)-4-(benzyloxy)-2,5-dimethylhexane-1,3-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 126587-67-5
(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

Guidance literature:: With dmap; triethylamine;
DOI:10.1016/S0040-4039(01)80647-X

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 126587-67-5
(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / H₂SO₄

2: 80 percent / TfOH

3: 89 percent / LAH

4: 70 percent / SO₃*pyridine, DMSO, Et₃N

5: 74 percent / SnCl₄ / CH₂Cl₂ / -78 °C

6: LAH

7: 100 percent / DMAP, Et₃N

With dmap; lithium aluminium tetrahydride; pyridine-SO₃ complex; trifluorormethanesulfonic acid; tin(IV) chloride; dimethyl sulfoxide; triethylamine; sulfuric acid; In dichloromethane;
DOI:10.1016/S0040-4039(01)80647-X

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 126587-67-5
(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

Guidance literature:: Multi-step reaction with 8 steps

1: 57 percent / 1N H₂SO₄, 1N NaNO₂

2: 87 percent / H₂SO₄

3: 80 percent / TfOH

4: 89 percent / LAH

5: 70 percent / SO₃*pyridine, DMSO, Et₃N

6: 74 percent / SnCl₄ / CH₂Cl₂ / -78 °C

7: LAH

8: 100 percent / DMAP, Et₃N

With dmap; lithium aluminium tetrahydride; pyridine-SO₃ complex; trifluorormethanesulfonic acid; sulfuric acid; tin(IV) chloride; dimethyl sulfoxide; triethylamine; sodium nitrite; sulfuric acid; In dichloromethane;
DOI:10.1016/S0040-4039(01)80647-X